EXPLORING COMPOUND PROMISCUITY PATTERNS AND MULTI-TARGET ACTIVITY SPACES

EXPLORING COMPOUND PROMISCUITY PATTERNS AND MULTI-TARGET ACTIVITY SPACES

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Compound promiscuity is rationalized as the specific interaction of a small molecule with multiple biological targets (as opposed to non-specific binding events) Earl Grey Tea and represents the molecular basis of polypharmacology, an emerging theme in drug discovery and chemical biology.This concise review focuses on recent studies that have provided a detailed picture of the degree of promiscuity Acne Treatment among different categories of small molecules.In addition, an exemplary computational approach is discussed that is designed to navigate multi-target activity spaces populated with various compounds.