Compound promiscuity is rationalized as the specific interaction of a small molecule with multiple biological targets (as opposed to non-specific binding events) Earl Grey Tea and represents the molecular basis of polypharmacology, an emerging theme in drug discovery and chemical biology.This concise review focuses on recent studies that have provi
To elucidate the network that maintains high fidelity genome replication, we have introduced two conditional mutant alleles of DNA2, an essential DNA replication gene, into each of the approximately 4,700 viable yeast deletion mutants and determined the fitness of the double mutants.Fifty-six DNA2-interacting genes were identified.Clustering analys
Abstract Energy conditions, especially the null energy condition (NEC), are generically imposed on solutions to retain a physically sensible classical field theory and they also play an important role in the AdS/CFT duality.Using this duality, we study non-trivially deformed strongly coupled quantum field theories at large-N c.The corresponding dua
Human motion monitoring and analysis can be an essential part of Cleaning Tools a wide spectrum of applications, including physical rehabilitation among other potential areas of interest.Creating non-invasive systems for monitoring patients while performing rehabilitation exercises, to provide them with an objective feedback, is one of the current